Predictors of thyroglobulin in the lymph nodes recurrence of papillary thyroid carcinoma undergoing total thyroidectomy

Abstract Background To investigate the association between postoperative lymph nodes (LNs) recurrence and distinct serum thyroglobulin (Tg) levels in patients with papillary thyroid carcinoma (PTC). Methods This study included PTC who underwent total thyroidectomy (TT) at least central neck dissection then re-operated due to of LNs January 2013 June 2018. These were grouped by negative or positive Tg according American Thyroid Association guidelines. Results Of 60 patients, 49 radioactive iodine (RAI) treatment. Maximum unstimulated (uTg) ? 0.2 ng/mL associated larger diameter recurrent ( P = 0.027), higher rate metastatic < 0.001). Serum-stimulated (off-Tg) 1 0.047) (on-Tg) ng/Ml 0.013) LNs. Number 8 was an independent predictor for maximum uTg (OR 8.767; 95% CI 1.392–55.216; 0.021). Ratio 25% off-Tg 20.997; 1.649–267.384; 0.019). Conclusion Postoperative Tg-positive status size ratio predicators uTg-positive off-Tg-positive status, respectively.